CHLOROQUINE DIPHOSPHATE

PRODUCT IDENTIFICATION
CAS NO. 50-63-5; 6384-82-3; 69698-56-2

CHLOROQUINE DIPHOSPHATE
EINECS NO. 200-055-2
FORMULA C18H26ClN3·2H3PO4
MOL WT. 515.87

H.S. CODE

 2933.49.2600

TOXICITY

 Oral Rat LD50: 623mg/kg
SYNONYMS Chloroquine Phosphate; Gontochin phosphate; Khingamin; Miniquine;
Diphosphate salt of N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine; 7-Chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat; Alermine; Aralen; Aralen diphosphate; Aralen phosphate; Arechin; Avloclor; Bemaphate; Chloroquine bis(phosphate); 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2); Chingamin; Chingamin phosphate; Chingaminum; Chlorochin diphosphate; Chloroquin diphosphate; Chloroquine dihydrogen phosphate; Nivaquine B; Quingamine; Resochin; Resoquine; Sanoquin; Tanakan;

SMILES

 c1c(cc2c(c(ccn2)N[C@@H](CCCN(CC)CC)C)c1)Cl.P(=O)(O)(O)O.P(=O) (O)(O)O

CLASSIFICATION

Antibiotic, Analgesics, Non-Narcotic, Anthelmintic, Anti-Infective, Anti-amebic, Anti-inflammatory agent non-steroidal; Antimalarial; Antinematodal, Antiparasitic, Antiprotozoal, Antirheumatic, Filaricide, Quinoline

EXTRA NOTES

 The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. Suppressant
Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinoline-based photoactive drug IAAQ (N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azidosalicylamide). 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 200 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS  

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Chloroquine

http://www.hopkinslupus.org/
Hydroxychloroquine (Plaquenil), chloroquine (Aralen), and quinacrine (Atabrine) are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Specifically, anti-malarial medications have shown to improve muscle and joint pain, skin rashes, pericarditis (inflammation of the lining of the heart), pleuritis (inflammation of the lining of the lung), and other lupus symptoms such as fatigue and fever. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system (your brain and spinal cord) and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. For this reason, you can think of anti-malarials as a sort of “lupus life insurance.” Studies have shown lupus patients on anti-malarials actually live longer than those who are not, and these medications are usually prescribed when someone is first diagnosed with the disease. Anti-malarials are particularly useful in treating discoid lupus, subacute cutaneous lupus, and mouth sores associated with lupus; they are also effective in treating rheumatoid arthritis and Sjogren’s syndrome. However, anti-malarials are not a sufficient treatment for more severe lupus symptoms such as kidney disease and nervous system or blood vessel involvement. When lupus spreads to these organs, immunosuppressive medications are usually added to help minimize irreversible injury.

Local:
Chloroquine is used as an drug to treat and prevent mainly malaria. Malaria is one of leading re-emerging infectious disease due to murative malarial parasite developed resistance to chloroquine. Sulfadoxine-pyrimethamine is an alternative can be used in the treatment of the disease resistant to chloroquine, but resistance to sulfadoxine-pyrimethamine has been reported also in some areas. Artemisinin is an alternative used in areas where the disease has become highly resistant to sulfadoxine-pyrimethamine. Chloroquine-resistant falciparum malaria should be treated with quinine sulfate, sulfonamide, doxycycline or with clindamycin. Other effective synthetic anti-malaria drugs are quinacrine, chloroquine, and primaquine. Vaccines against malaria are still experimental.

Chloroquine Molecules

Product

CAS RN

Chloroquine phosphate

50-63-5
Chloroquine 54-05-7
Chloroquine 4-acetaminosalicylate 58-77-5
Chlorquinaldol 72-80-0
3-Methylchloroquine 85-10-9
3-Carboxy-4-hydroxy-7-chloroquinoline 86-47-5
4,7-Dichloroquinoline 86-98-6
7-Chloro-4-hydroxyquinoline 86-99-7
6-Chloroquinaldine 92-46-6
N,2,6-Trichloro-4-benzoquinone imine 101-38-2
Hydroxychloroquine 118-42-3
Chloranil 118-75-2
Clioquinol 130-26-7
Cloxyquin 130-16-5
Chloroquine sulfate 132-73-0
8-Chloroquinoline 611-33-6
4-Chloroquinoline 611-35-8
3-Chloroquinoline 612-59-9
6-Chloroquinoline 612-57-7
2-Chloroquinoline 612-62-4
2-Chloro-1,4-hydroxyquinone 615-67-8
5-Chloroquinoline 635-27-8
2-Chloro-1,4-benzoquinone 695-99-8
2,6-Dichlorobenzoquinone 697-91-6
Hydroxychloroquine sulfate 747-36-4
Chloroxine 773-76-2
7-Chloroquinolin-8-ol 876-86-8
Chloroquinine phosphate 1446-17-9
2-Chloroquinoxaline 1448-87-9
Desethylchloroquine 1476-52-4
2,3-Dichloroquinoxaline-6-carbonylchloride 1919-43-3
2,3-Dichloroquinoxaline 2213-63-0
2-Chloroquinoline-4-carbonyl chloride 2388-32-1
4,11-Dichloroquinacridonequinone 2389-75-5
2,9-Dichloroquino(2,3-b)acridine-6,7,13,14(5H,12H)-tetrone 2490-60-0
2,3,6-Trichloroquinoxaline 2958-87-4
Chlorquinox 3495-42-9
Chloroquine hydrochloride 3545-67-3
Glafenine 3820-67-5
Chloroquine mustard 4213-44-9
N,N-Dideethylchloroquine 4298-14-0
Cletoquine 4298-15-1
Chloroquine-ethyl phenyl mustard 4465-92-3
4-Chloroquinazoline 5190-68-1
4-(3',5'-Bis(pyrrolidinomethyl)-4-hydroxyanilino)-7-chloroquinoline 5201-88-7
6-Chloroquinoxaline 5448-43-1
6-Chloro-8-aminoquinoline 5470-75-7
2-Chloromethyl-4-phenyl-6-chloroquinazoline-3-oxide 5958-24-7
2-Chloroquinazoline 6141-13-5
4-(2-Methyl-1-pyrrolidyl)-7-chloroquinoline 6281-58-9
6,7-Dichloroquinoline-5,8-dione 6541-19-1
6,7-Dichloroquinoxaline-2,3-dione 6639-79-8
Cloquinate 7270-12-4
8-Quinolinol, 7-bromo-5-chloro- 7640-33-7

Collagenan

8055-81-0
Dichlorquinazine 10547-40-7
4,7-Dichloroquinolinium tribromide 12365-92-3
Chloroquinoline 15847-17-3
Chloroquine diorotate 16301-30-7
2,4,6-Triamino-5-chloroquinazoline 17511-20-5
Methyl-8-(5,7-dichloroquinolyl)carbonic acid ester 18119-52-3
6-Amino-7-chloro-5,8-dioxoquinoline 18892-39-2
4,8-Dichloroquinoline 21617-12-9
5-Chloroquinolin-8-ol hydrochloride 25395-13-5
3-Phenyl-4-hydroxy-7-chloroquinolin-2(1H)-one 28563-19-1
N-Methyl-6-chloroquinolinium iodide 32596-83-1
3-Chloroquinuclidine hydrochloride 33601-77-3
Halacrinate 34462-96-9
1-Phenacyloxime-4,5-dichloroquinolinium chloride hydrate 36226-69-4
Chloroquine diascorbate 38305-48-5
2-(7-Chloroquinolin-4-yl)anthranilic acid hidrochloride 53560-21-7
Tripiperaquine 53658-96-1
2-(2-Chlorostyryl)-4-(delta-diethylamino-alpha-methylbutylamino)-7-chloroquinazoline 57942-32-2
(+)-Chloroquine 58175-86-3
(-)-Chloroquine 58175-87-4
7-Chloro-4-(3-octylaminopropyl)aminoquinoline 1-oxide 63680-59-1
Ethyl chloroquine mustard 63717-15-7
L-Chloroquine 67459-54-5
2,6-Dianilino-6-chloroquinoxaline 68413-85-4
2-(2-(5-Nitrofuryl)vinyl)-4-(delta-diethylamino-alpha-methylbutylamino)-7-chloroquinazoline 69258-64-6
D-Chloroquine 69698-55-1
2,3-Bis(allylamino)-6-chloroquinoxaline 71205-46-4
7-Chloroquinolin-4-ol hydrochloride 71799-41-2
2-Amino-3,4-dichloroquinoline 73987-35-6
Quizalofop 76578-12-6

Presocyl

 78456-99-2
Tris(5,7-dichloroquinolin-8-olato-N1,O8)aluminium 78970-14-6

Contramibial

 83097-13-6
Quinclorac 84087-01-4
N-(4-((7-Chloroquinolin-4-yl)amino)pentyl)-N-ethylacetamide 91828-61-4
7-Bromo-5-chloroquinolin-ol 94275-80-6
Chlorsulfaquinoxaline 97919-22-7
1-Dimethylaminopropyl-3-methyl-6-chloroquinoxaline-2(1H)-one 102582-79-6
Propaquizafop 111479-05-1
3-Chloroquinoline-8-carboxylic acid 125300-42-7
5,10,15,20-Tetraphenyl-1-3-(4-(4-aminobutyl)-7-chloroquinoline)propioamidoporphine 130170-25-1
4-((Carboxymethyl)amino)-5,7-dichloroquinoline-2-carboxylic acid 130613-18-2
4-((Carboxymethyl)oxy)-5,7-dichloroquinoline-2-carboxylic acid 130613-17-1
5,7-Dichlorokynurenic acid 131123-76-7
N1,N2-Bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamine 140926-77-8
Meclinertant 146362-70-1
5-(2-(1-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)benzyl)indol-7-yl)ethyl)-1H-tetrazole 146554-87-2
(N1-(7-Chloroquinolin-4-yl)-3-(N3,N3-diethylamino)propylamine) dihydrochloride trihydrate 169815-40-1
SALES SPECIFICATION (USP, BP)

APPEARANCE

 white crystalline powder

ASSAY

96.0 % min

WATER

3.0% max
TRANSPORTATION
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